Sequence variation in microRNA-34a is associated with diabetes mellitus susceptibility in a southwest Chinese Han population.

ABSTRACT: Type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) seriously impact the prognosis and survival of patients. Abundant studies suggest that single nucleotide polymorphisms (SNPs) within regulatory regions of miRNAs modulate progression of various diseases including DM and DN. However, evidence for exploring the mechanism in DM and DN are still insufficient. This study was performed to discuss the association of SNPs in the regulatory region of hsa-miR-34a with DM or DN susceptibility in the southwest Chinese Han population. Three SNPs (rs12128240, rs2666433, rs6577555) in miR-34a were analyzed in the T2DM patients with or without DN and normal controls. RT-qPCR was performed to measure expression of miR-34a. Real-time PCR was used for amplification of SNPs. MiR-34a was over-expres

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6958157 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature