Free amino acid profiling of gastric juice as a method for discovering potential biomarkers of early gastric cancer.

ABSTRACT: Background: Prior studies showed that aromatic amino acids (AAAs) could be used as potential gastric juice biomarkers in screening gastric cancer (GC). To identify new biomarkers for early diagnosis of GC, the characteristics of gastric juice free amino acid (GJFAA) profiling was determined. Method: First, gastric juice was collected from 130 consecutive patients who underwent gastroscopy. They were divided into GC group (n = 47) and non-neoplastic gastric disease (NGD) group (n = 83) according to the pathological diagnosis. The concentrations of 34 GJFAAs were examined by amino acid analyzer. Multivariate and univariate analyses were used for comparing the alterations of GJFAA profiles between the two groups. Then candidate differential GJFAAs were verified by LC-MS/MS in another set of p

SUBMITTER: Liu J 

PROVIDER: S-EPMC6958230 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature