Toward understanding polymer micelle stability: Density ultracentrifugation offers insight into polymer micelle stability in human fluids.

ABSTRACT: Micelles, as a class of drug delivery systems, are underrepresented among United States Food and Drug Administration approved drugs. A lack of clinical translation of these systems may be due to, in part, to a lack of understanding of micelle interactions with biologic fluids following injection. Despite the limited clinical translation, micelles remain an active area of research focus and pre-clinical development. The goal of the present study was to examine the stability of amphiphilic block copolymer micelles in biologic fluids to identify the properties and components of biologic fluids that influence micelle stability. Micelle stability, measured via Förster resonance energy transfer-based fluorescent spectrometry, was complemented with density ultracentrifugation to reveal the coloca

SUBMITTER: Langridge TD 

PROVIDER: S-EPMC6958513 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature