Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members.

ABSTRACT: BACKGROUND:There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury. METHODS:We conducted a repeated measures, case-control study, examining associations of serum levels of pro- and anti-inflammatory cytokines, measured both pre- and post-deployment with having mild and moderate/severe bTBI. Utilizing serum from the Department of Defense Serum Repository cytokines were measured via an ELISA-based array for 15 cytokines. We compared pre- vs. post-levels among mild cases, moderate/severe cases, and controls and carried out case-control comparisons, using paired t- tests and generalized linear models. RESULTS:The average time between bTBI and post-deploymen

SUBMITTER: Rusiecki J 

PROVIDER: S-EPMC6958571 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature