VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.

ABSTRACT:

Rationale

Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3 also regulates sprouting angiogenesis and blood vessel growth, but to what extent VEGFR3 signaling controls blood vessel permeability remains unknown.

Objective

To investigate the role of VEGFR3 in the regulation of VEGF-induced vascular permeability.

Methods and results

Long-term global Vegfr3 gene deletion in adult mice resulted in increased fibrinogen deposition in lungs and kidneys, indicating enhanced vascular leakage at the steady state. Short-term deletion of Vegfr3 in blood vascular endothelial cells increased baseline leakage i

SUBMITTER: Heinolainen K 

PROVIDER: S-EPMC6959003 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature