MYD88 in the driver's seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications.

ABSTRACT: More than 50 subtypes of B-cell non-Hodgkin lymphoma (B-NHL) are recognized in the most recent World Health Organization classification of 2016. The current treatment paradigm, however, is largely based on 'one-size-fits-all' immune-chemotherapy. Unfortunately, this therapeutic strategy is inadequate for a significant number of patients. As such, there is an indisputable need for novel, preferably targeted, therapies based on a biologically driven classification and risk stratification. Sequencing studies identified mutations in the MYD88 gene as an important oncogenic driver in B-cell lymphomas. MYD88 mutations constitutively activate NF-κB and its associated signaling pathways, thereby promoting B-cell proliferation and survival. High frequencies of the hotspot MYD88(L265P) mutation are

SUBMITTER: de Groen RAL 

PROVIDER: S-EPMC6959184 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature