Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia.

ABSTRACT: Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and Sowa-Rigpa) have been used from centuries for the treatment vascular diseases and dementia. This traditional knowledge can be transformed into novel targets through robust interplay of network pharmacology (NetP) with reverse pharmacology (RevP), without ignoring cutting edge biomedical data. This work demonstrates interaction between recent and traditional data, and aimed at selection of most promising targets for guiding wet lab validations. PROTEOME, DisGeNE, DISEASES and DrugBank databases were used for selection of genes associated wi

SUBMITTER: Lagunin AA 

PROVIDER: S-EPMC6959222 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature