Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome.

ABSTRACT: Little attention was given to the interaction between tumor and stromal cells in urothelial bladder carcinoma (UBC). While recent studies point towards the existence of different fibroblast subsets, no comprehensive analyses linking different fibroblast markers to UBC patient survival have been performed so far. Through immunohistochemical analysis of five selected fibroblast markers, namely alpha smooth muscle actin (ASMA), CD90/Thy-1, fibroblast activation protein (FAP), platelet derived growth factor receptor-alpha and -beta (PDGFRa,-b), this study investigates their association with survival and histopathological characteristics in a cohort of 344 UBC patients, involving both, muscle-invasive and non-muscle-invasive cases. The data indicates that combinations of stromal markers are mor

SUBMITTER: Mezheyeuski A 

PROVIDER: S-EPMC6959241 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature