Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch at the whole transcriptome level.

ABSTRACT: The central role that erythrocyte invasion plays in Plasmodium falciparum survival and reproduction makes this process an attractive target for therapeutic or vaccine development. However, multiple invasion-related genes with complementary and overlapping functions afford the parasite the plasticity to vary ligands used for invasion, leading to phenotypic variation and immune evasion. Overcoming the challenge posed by redundant ligands requires a deeper understanding of conditions that select for variant phenotypes and the molecular mediators. While host factors including receptor heterogeneity and acquired immune responses may drive parasite phenotypic variation, we have previously shown that host-independent changes in invasion phenotype can be achieved by continuous culturing of the W2m

SUBMITTER: Nyarko PB 

PROVIDER: S-EPMC6959351 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature