Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.

ABSTRACT: Lower respiratory infections, such as community-acquired pneumonia (CAP), and chronic obstructive pulmonary disease (COPD) rank among the most frequent causes of death worldwide. Improved diagnostics and profound pathophysiological insights are urgent clinical needs. In our cohort, we analysed transcriptional networks of peripheral blood mononuclear cells (PBMCs) to identify central regulators and potential biomarkers. We investigated the mRNA- and miRNA-transcriptome of PBMCs of healthy subjects and patients suffering from CAP or AECOPD by microarray and Taqman Low Density Array. Genes that correlated with PBMC composition were eliminated, and remaining differentially expressed genes were grouped into modules. One selected module (120 genes) was particularly suitable to discriminate AECOP

SUBMITTER: Bertrams W 

PROVIDER: S-EPMC6959367 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature