Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology.

ABSTRACT: The term 'immunogenic cell death' (ICD) denotes an immunologically unique type of regulated cell death that enables, rather than suppresses, T cell-driven immune responses that are specific for antigens derived from the dying cells. The ability of ICD to elicit adaptive immunity heavily relies on the immunogenicity of dying cells, implying that such cells must encode and present antigens not covered by central tolerance (antigenicity), and deliver immunostimulatory molecules such as damage-associated molecular patterns and cytokines (adjuvanticity). Moreover, the host immune system must be equipped to detect the antigenicity and adjuvanticity of dying cells. As cancer (but not normal) cells express several antigens not covered by central tolerance, they can be driven into ICD by some thera

SUBMITTER: Vanmeerbeek I 

PROVIDER: S-EPMC6959434 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature