Nitrogen-bound diazeniumdiolated amidines.

ABSTRACT: In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.

SUBMITTER: Biswas D 

PROVIDER: S-EPMC6959519 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature