Enhancing the Bystander and Abscopal Effects to Improve Radiotherapy Outcomes.

ABSTRACT: In this paper, we summarize published articles and experiences related to the attempt to improve radiotherapy outcomes and, thus, to personalize the radiation treatment according to the individual characteristics of each patient. The evolution of ideas and the study of successively published data have led us to envisage new biophysical models for the interpretation of tumor and healthy normal tissue response to radiation. In the development of the model, we have shown that when mesenchymal stem cells (MSCs) and radiotherapy are administered simultaneously in experimental radiotherapy on xenotumors implanted in a murine model, the results of the treatment show the existence of a synergic mechanism that is able to enhance the local and systemic actions of the radiation both on the treated tu

SUBMITTER: Farias VA 

PROVIDER: S-EPMC6960107 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature