RBP2 stabilizes slow Cav1.3 Ca²⁺ channel inactivation properties of cochlear inner hair cells.

ABSTRACT: Cav1.3 L-type Ca²⁺ channels (LTCCs) in cochlear inner hair cells (IHCs) are essential for hearing as they convert sound-induced graded receptor potentials into tonic postsynaptic glutamate release. To enable fast and indefatigable presynaptic Ca²⁺ signaling, IHC Cav1.3 channels exhibit a negative activation voltage range and uniquely slow inactivation kinetics. Interaction with CaM-like Ca²⁺-binding proteins inhibits Ca²⁺-dependent inactivation, while the mechanisms underlying slow voltage-dependent inactivation (VDI) are not completely understood. Here we studied if the complex formation of Cav1.3 LTCCs with the presynaptic active zone proteins RIM2α and RIM-binding protein 2 (RBP2) can stabilize slow VDI. We detected both RIM2α and RBP isoforms

SUBMITTER: Ortner NJ 

PROVIDER: S-EPMC6960213 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature