Ontology highlight
ABSTRACT:
SUBMITTER: Brzeska H
PROVIDER: S-EPMC6960411 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Brzeska Hanna H Gonzalez Jesus J Korn Edward D ED Titus Margaret A MA
Molecular biology of the cell 20191127 2
Myosin 1s have critical roles in linking membranes to the actin cytoskeleton via direct binding to acidic lipids. Lipid binding may occur through PIP3/PIP2-specific PH domains or nonspecific ionic interactions involving basic-hydrophobic (BH) sites but the mechanism of myosin 1s distinctive lipid targeting is poorly understood. Now we show that PH domains occur in all <i>Dictyostelium</i> myosin 1s and that the BH sites of Myo1A, B, C, D, and F are in conserved positions near the β3/β4 loops of ...[more]