Composite Central Face Design-An Approach to Achieve Efficient Alginate Microcarriers.

ABSTRACT: Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-

SUBMITTER: Valente JFA 

PROVIDER: S-EPMC6960800 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature