Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways.

ABSTRACT: Ageing-associated changes in the protein coding transcriptome have been extensively characterised, but less attention has been paid to the non-coding portion of the human genome, especially to long non-coding RNAs (lncRNAs). Only a minority of known lncRNAs have been functionally characterised; however, a handful of these lncRNAs have already been linked to ageing-associated processes. To gain more information on the effects of ageing on lncRNAs, we identified from GTEx data lncRNAs that show ageing-associated expression patterns (age-lncRNAs) in 29 human tissues in 20-79-year-old individuals. The age-lncRNAs identified were highly tissue-specific, but the protein coding genes co-expressed with the age-lncRNAs and the functional categories associated with the age-lncRNAs showed significant

SUBMITTER: Marttila S 

PROVIDER: S-EPMC6961210 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature