Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial.

ABSTRACT:

Background

Phase III trials often require large sample sizes, leading to high costs and delays in clinical decision-making. Group sequential designs can improve trial efficiency by allowing for early stopping for efficacy and/or futility and thus may decrease the sample size, trial duration and associated costs. Bayesian approaches may offer additional benefits by incorporating previous information into the analyses and using decision criteria that are more practically relevant than those used in frequentist approaches. Frequentist group sequential designs have often been used for phase III studies, but the use of Bayesian group sequential designs is less common. The aim of this work was to explore how Bayesian group sequential designs could be constructed for phase III trials cond

SUBMITTER: Ryan EG 

PROVIDER: S-EPMC6961266 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature