Simultaneous reduction of flow and fraction of inspired oxygen (FiO₂) versus reduction of flow first or FiO₂ first in patients ready to be weaned from high-flow nasal cannula oxygen therapy: study protocol for a randomized controlled trial (SLOWH trial).

ABSTRACT:

Background

High-flow nasal cannula (HFNC) oxygen therapy has been widely used in critically ill patients. Despite the effectiveness of HFNC as a treatment, optimal methods to withdraw HFNC after recovery from preexisting conditions have not been investigated to date. In this study, we will evaluate the safety and efficacy of simultaneous reduction of flow and fraction of inspired oxygen (FiO₂) compared with sequential reduction of either flow first or FiO₂ reduction first in patients with HFNC.

Methods/design

This is a prospective, investigator-initiated, randomized controlled trial with three experimental intervention groups. A total of 100 adult patients receiving HFNC and satisfying weaning criteria will be enrolled and randomly assigned to one of th

SUBMITTER: Kim MC 

PROVIDER: S-EPMC6961313 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature