Alternative splicing coupled with transcript degradation modulates OAS1g antiviral activity.

ABSTRACT: At the heart of an innate immune response lies a tightly regulated gene expression program. This precise regulation is crucial because small changes can shift the balance from protective to destructive immunity. Here we identify a frequently used alternative splice site in the gene oligoadenylate synthetase 1g (Oas1g), a key component of the 2-5A antiviral system. Usage of this splice site leads to the generation of a transcript subject to decay, and removal of the site leads to increased expression of Oas1g and an improved antiviral response. However, removal of the splice site also leads to an increase in apoptotic cell death, suggesting this splicing event exists as a compromise between the pathogen protective benefits and collateral damage associated with OAS1g activity.

SUBMITTER: Frankiw L 

PROVIDER: S-EPMC6961538 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature