Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.

ABSTRACT: Cell fate commitment involves the progressive restriction of developmental potential. Recent studies have shown that this process requires not only shifts in gene expression but also an extensive remodeling of the epigenomic landscape. To examine how chromatin states are reorganized during cellular specification in an in vivo system, we examined the function of pioneer factor TFAP2A at discrete stages of neural crest development. Our results show that TFAP2A activates distinct sets of genomic regions during induction of the neural plate border and specification of neural crest cells. Genomic occupancy analysis revealed that the repertoire of TFAP2A targets depends upon its dimerization with paralogous proteins TFAP2C and TFAP2B. During gastrula stages, TFAP2A/C heterodimers activate

SUBMITTER: Rothstein M 

PROVIDER: S-EPMC6961570 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature