Three-Dimensional Graphene Enhances Neural Stem Cell Proliferation Through Metabolic Regulation.

ABSTRACT: Graphene consists of two-dimensional sp2-bonded carbon sheets, a single or a few layers thick, which has attracted considerable interest in recent years due to its good conductivity and biocompatibility. Three-dimensional graphene foam (3DG) has been demonstrated to be a robust scaffold for culturing neural stem cells (NSCs) in vitro that not only supports NSCs growth, but also maintains cells in a more active proliferative state than 2D graphene films and ordinary glass. In addition, 3DG can enhance NSCs differentiation into astrocytes and especially neurons. However, the underlying mechanisms behind 3DG's effects are still poorly understood. Metabolism is the fundamental characteristic of life and provides substances for building and powering the cell. Metabolic activity is tightl

SUBMITTER: Fang Q 

PROVIDER: S-EPMC6961593 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature