In-depth characterization of the placental imprintome reveals novel differentially methylated regions across birth weight categories.

ABSTRACT: Imprinted genes play a pivotal role in placental processes underlying fetal development, and much interest centers on discerning whether these loci, via changes in DNA methylation and/or gene expression, inform disruptions in appropriate fetal growth. In this study, we comprehensively profiled DNA methylation across the placental imprintome and assessed the relationship with gene expression levels and aberrant fetal growth.Placental DNA methylation across 153 imprinted loci, including imprint control regions (ICR) and surrounding non-ICR regions, was surveyed using the Nimblegen TruSeq bisulfite sequencing platform among participants enrolled in the Rhode Island Child Health Study (RICHS, n = 163). Methylation and gene expression associations were assessed using eQTM analysis. Differential

SUBMITTER: Deyssenroth MA 

PROVIDER: S-EPMC6961688 | biostudies-literature | 2020 Jan - Feb

REPOSITORIES: biostudies-literature