Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability.

ABSTRACT: The malignancy potential is correlated with the mechanical deformability of the cancer cells. However, mechanical tests for clinical applications are limited. We present here a Triangular Correlation (TrC) between cell deformability, phagocytic capacity, and cancer aggressiveness, suggesting that phagocytic measurements can be a mechanical surrogate marker of malignancy. The TrC was proved in human prostate cancer cells with different malignancy potential, and in human bladder cancer and melanoma cells that were sorted into subpopulations based solely on their phagocytic capacity. The more phagocytic subpopulations showed elevated aggressiveness ex vivo and in vivo. The uptake potential was preserved, and differences in gene expression and in epigenetic signature were detected. In all case

SUBMITTER: Brill-Karniely Y 

PROVIDER: S-EPMC6962040 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature