An efficient analytical reduction of detailed nonlinear neuron models.

ABSTRACT: Detailed conductance-based nonlinear neuron models consisting of thousands of synapses are key for understanding of the computational properties of single neurons and large neuronal networks, and for interpreting experimental results. Simulations of these models are computationally expensive, considerably curtailing their utility. Neuron_Reduce is a new analytical approach to reduce the morphological complexity and computational time of nonlinear neuron models. Synapses and active membrane channels are mapped to the reduced model preserving their transfer impedance to the soma; synapses with identical transfer impedance are merged into one NEURON process still retaining their individual activation times. Neuron_Reduce accelerates the simulations by 40-250 folds for a variety of cell types

SUBMITTER: Amsalem O 

PROVIDER: S-EPMC6962154 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature