Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars.

ABSTRACT: Salmonella enterica infections remain a challenging health issue, causing significant morbidity and mortality worldwide. Current vaccines against typhoid fever display moderate efficacy whilst no licensed vaccines are available for paratyphoid fever or invasive non-typhoidal salmonellosis. Therefore, there is an urgent need to develop high efficacy broad-spectrum vaccines that can protect against typhoidal and non-typhoidal Salmonella. The Salmonella outer membrane porins OmpC and OmpF, have been shown to be highly immunogenic antigens, efficiently eliciting protective antibody, and cellular immunity. Furthermore, enterobacterial porins, particularly the OmpC, have a high degree of homology in terms of sequence and structure, thus making them a suitable vaccine candida

SUBMITTER: Valero-Pacheco N 

PROVIDER: S-EPMC6962181 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature