Postprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes.

ABSTRACT: While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Male:Female = 1:1); grouped into first degree relatives of patients with T2DM (n = 30), those with a body mass index >23 kg/m² but <30 kg/m² (n = 30), those with prediabetes (n = 20) and normal controls (n = 30). We performed an untargeted metabolomics analysis of plasma and related that with clinical and biochemical parameters, markers of inflammation, and insulin sensitivity. Similar to prediabetes subjects, overweight subjects had insulin resistance and significantly elevated

SUBMITTER: Kumar AA 

PROVIDER: S-EPMC6962374 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature