Comparative analysis of pathophysiological parameters between emphysematous smokers and emphysematous patients with COPD.

ABSTRACT: Emphysematous smokers with normal spirometry form a considerable proportion of the clinical population. However, despite presenting with respiratory symptoms and activity limitation, they cannot be diagnosed with chronic obstructive lung disease (COPD) according to current criteria. Thus, we aimed to determine whether emphysema in smokers has a different pathogenesis from that in patients with COPD. We compared 12 pairs of lung tissue samples from emphysematous patients with normal spirometry and COPD, and determined the degree of emphysema using computed tomography. With a focus on COPD-related pathogenesis, we independently assessed inflammatory response, protease-antiprotease balance, oxidative stress, and apoptosis in both groups. Both groups showed similar pathological changes at a co

SUBMITTER: Bai S 

PROVIDER: S-EPMC6962428 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature