Cathepsin C Interacts with TNF-α/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.

ABSTRACT:

Purpose

Although cathepsin C (CTSC) has been reported to maintain malignant biological properties in various cancers, its functions in hepatocellular carcinoma (HCC) remain obscure. We aimed to investigate the potential role of CTSC in HCC.

Materials and methods

HCC tissue microarrays (n=122) were employed to analyze the correlation between CTSC expression and clinicopathological characteristics through immunohistochemistry staining. Quantitative real-time polymerase chain reaction, western blot assay, Cell Counting Kit-8 assay, colony formation, cell migration, and invasion assays, xenograft mice model were adopted to validate what had been indicated by the bioinformatic web tools.

Results

By bioinformatic tools and tissue microarrays, CTSC was found upregulated in H

SUBMITTER: Zhang GP 

PROVIDER: S-EPMC6962486 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature