Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection.

ABSTRACT: The protozoan parasite Cryptosporidium parvum (CP) causes cryptosporidiosis, a diarrheal disease worldwide. Infection in immunocompetent hosts typically results in acute, self-limiting, or recurrent diarrhea. However, in immunocompromised individuals infection can cause fulminant diarrhea, extraintestinal manifestations, and death. To date, the mechanisms underlying CP-induced diarrheal pathogenesis are poorly understood. Diarrheal diseases most commonly involve increased secretion and/or decreased absorption of fluid and electrolytes. We and others have previously shown impaired chloride absorption in infectious diarrhea due to dysregulation of SLC26A3 [downregulated in adenoma (DRA)], the human intestinal apical membrane Cl^-/HCO3- exchanger protein. However, there are n

SUBMITTER: Kumar A 

PROVIDER: S-EPMC6962516 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature