Overexpression of trophoblast cell surface antigen 2 is associated with BRAF V600E mutation and aggressive behavior in papillary thyroid cancer.

ABSTRACT: BACKGROUND:Papillary thyroid cancer (PTC) is the most common endocrine tumor with an increasing incidence. The dilemma in treating this cancer is how to discriminate the tumors with aggressive behavior from the indolent ones. Trophoblast cell surface antigen 2 (trop-2) has been identified in multiple epithelial cancers and proven to be associated with shortened overall survival and disease-free survival. METHODS:In this study, we retrospectively collected the clinicopathologic characteristics of 145 patients who underwent surgery at Fudan University Shanghai Cancer Center (FUSCC), and a validation cohort from The Cancer Genome Atlas (TCGA) database was identified to support the conclusion. Quantitative real-time polymerase chain reaction (qPCR) was employed to determine trop-2 mRNA in canc

SUBMITTER: Guan Q 

PROVIDER: S-EPMC6962772 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature