FOXM1 as a prognostic biomarker promotes endometrial cancer progression via transactivation of SLC27A2 expression.

ABSTRACT: Endometrial cancer (EC) is one of the most important gynecological cancers, but its pathogenesis is not clearly understood, and it also lacks an effective treatment. The nuclear transcriptional protein forkhead box protein M1 (FOXM1) has crucial functions in the development and progression of cancer and is treated as a prognostic biomarker and therapeutic target in many types of cancers. However, the situation and underlying mechanisms of FOXM1's involvement in EC is largely underestimated. In our present study, we found FOXM1 was overexpressed in EC, including endometrioid (EEC) and serous (SEC). High expression of FOXM1 was meaningfully associated with a poor prognosis of EC patients as well as with EC pathological stages and clinical grades. Knocking down FOXM1 could significantly reduc

SUBMITTER: Feng Y 

PROVIDER: S-EPMC6962789 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature