Genotypicdiversity of drug-resistant Mycobacterium tuberculosis isolates from Hebei, China.

ABSTRACT: Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant tuberculosis (MDR-TB), has been identified as a major challenge for effective TB control. For rapid detection and proper treatment, molecular assays based on the identification of mutations in genes associated with drug resistance have been established to determine drug resistance. However, there is as yet little information about drug resistance-associated mutations of clinical Mycobacterium tuberculosis isolates from Hebei. In this study, four genetic loci katG, inhA, oxyR-ahpC intergenic region and rpoB were sequenced among 276 DR-TB isolates from Hebei to understand the association between specific mutations, drug resistance phenotypes and spoligotyping genotypes. Altogether, 83.8%

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6962832 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature