Aqueous humor metabolomic profiles in association with diabetic mellitus.

ABSTRACT: Diabetic mellitus (DM), commonly referred to diabetes, is a worldwide metabolic disorder, which usually causes high morbidity and mortality rates. Especially, DM may result in serious macrovascular problems including cataract. To investigate the underlying molecular mechanism, here we for the first time employed gas chromatography-time-of-flight mass spectrometry (GC-TOF MS) for an untargeted metabolomics study. Totally 263 metabolites were determined in aqueous humor (AH) samples from 30 patients: 15 for the controls and 15 with DM. Both the heat map and principal component analysis (PCA) plot showed a significantly distinct metabolomics profiles between patients with DM and the controls. Moreover, 20 metabolites were determined to be significantly altered (P ≤ 0.05) in DM patients, some

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6962866 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature