Characterization of desmoglein 2 expression in ovarian serous tumors and its prognostic significance in high-grade serous carcinoma.

ABSTRACT: Desmogleins (Dsgs) are major members of the desmosomal cadherins that are critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. DSG2 is the most ubiquitous desmosomal cadherin; however, abnormal expression of DSG2 has been detected in several types of cancer with controversial results. So far, little is known about DSG2 expression in ovarian serous tumor (OST) and its associations with survival and clinicopathologic data. In this study, mRNA and protein expression of DSG2 was detected in 33 cases of nonfixed samples and 92 cases of paraffin-embedded OST specimens (including benign, borderline, low-grade, and high-grade) by using qRT-PCR and immunohistochemistry, respectively. DSG2 expression was then measured in 162 cases of high-grade se

SUBMITTER: Chen L 

PROVIDER: S-EPMC6962919 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature