Discovery of microarray-identified genes associated with the progression of cervical intraepithelial neoplasia.

ABSTRACT: OBJECTIVE:To identify genes potentially associated with cervical intraepithelial neoplasia (CIN) progression through bioinformatic approaches and clinicopathological verification. METHODS:mRNA expression microarray data related to CIN progression were screened from the Gene Expression Omnibus (GEO) database and re-analyzed using bioinformatics approaches. Tissue microarray immunohistochemistry was conducted to assess the significant identified genes in CIN, cervical cancer, and normal tissues. RESULTS:Biological annotation and text mining showed that 14 differentially expressed genes were directly or indirectly related to CIN progression. The expression of 5 up-regulated differentially expressed genes, namely, CCND2, TGFBR2, PRKCB, SH3KBP1 and WNT2B, was examined by tissue microarray immun

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC6963088 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature