Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections.

ABSTRACT: Despite medical progress, more than a billion people still suffer daily from parasitic infections. Vaccination is recognized as one of the most sustainable options to control parasitic diseases. However, the development of protective and therapeutic vaccines against tropical parasites has proven to be exceptionally challenging for both scientific and economic reasons. For certain parasitic diseases, traditional vaccine platforms are not well-suited, due to the complexity of the parasite life cycles and the parasite's ability to evade the human immune system. An effective anti-parasite vaccine platform needs to have the ability to develop and test novel candidate antigens fast and at high-throughput; it further needs to allow for multivalent combinations and must evoke a strong and well-def

SUBMITTER: Versteeg L 

PROVIDER: S-EPMC6963228 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature