Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties.

ABSTRACT: Transmucosal drug delivery is a promising avenue to improve therapeutic efficacy through localized therapeutic administration. Drug delivery systems that increase retention in the mucosal layer are needed to improve efficiency of such transmucosal platforms. However, the applicability of such systems is often limited by the range of chemistries and properties that can be achieved. Here we present the design and implementation of silk-elastin-like proteins (SELPs) with mucoadhesive properties. SELP-based micellar-like nanoparticles provide a system to tailor chemical and physical properties through genetic engineering of the SELP sequence, which enables the fabrication of nanoparticles with specific chemical and physical features. Analysis of the adhesion of four different SELP-based nanopa

SUBMITTER: Parker RN 

PROVIDER: S-EPMC6963467 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature