Immunosuppressive Compounds Affect the Fungal Growth and Viability of Defined Aspergillus Species.

ABSTRACT: Immunosuppressive drugs are administered to a number of patients; e.g., to allogeneic hematopoietic stem cell transplant recipients. Immunosuppressive drugs impair the immune system and thus increase the risk of invasive fungal disease, but may exhibit antifungal activity at the same time. We investigated the impact of various concentrations of three commonly used immunosuppressive compounds-cyclosporin A (CsA), methylprednisolone (mPRED), and mycophenolic acid (MPA)-on the growth and viability of five clinically important Aspergillus species. Methods included disc diffusion, optical density of mycelium, and viability assays such as XTT. MPA and CsA had a species-specific and dose-dependent inhibitory effect on the growth of all Aspergillus spp. tested, although growth inhibition by MPA wa

SUBMITTER: Schmidt S 

PROVIDER: S-EPMC6963520 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature