Efficient Delivery of Dengue Virus Subunit Vaccines to the Skin by Microprojection Arrays.

ABSTRACT: Dengue virus is the most important arbovirus impacting global human health, with an estimated 390 million infections annually, and over half the world's population at risk of infection. While significant efforts have been made to develop effective vaccines to mitigate this threat, the task has proven extremely challenging, with new approaches continually being sought. The majority of protective, neutralizing antibodies induced during infection are targeted by the envelope (E) protein, making it an ideal candidate for a subunit vaccine approach. Using truncated, recombinant, secreted E proteins (sE) of all 4 dengue virus serotypes, we have assessed their immunogenicity and protective efficacy in mice, with or without Quil-A as an adjuvant, and delivered via micropatch array (MPA) to the ski

SUBMITTER: Muller DA 

PROVIDER: S-EPMC6963636 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature