Multivariate Comparison of Cytokine Profiles for Normal- and Low-Bone-Density Subjects.

ABSTRACT: Osteoporosis is a serious worldwide public health concern. The role of the immune system in the onset of osteoporosis in postmenopausal women is an area of current research. Here we study data from a panel of 10 cytokines obtained from postmenopausal women, with both normal and low bone mineral density (BMD). Normal- and low-BMD groups are compared and contrasted, and further low-BMD participants are sub-classified into osteopenic and osteoporotic based on BMD levels, and compared to each other. Via the use of multivariate statistical tools, we examine contrasting groups in relation to: (a) the presence of subgroups/clusters; (b) whether groups have statistically different multivariate distributions; (c) how strongly groups differ (if at all), which relates to the practical/clinical signif

SUBMITTER: Dingle K 

PROVIDER: S-EPMC6963703 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature