Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?

ABSTRACT: The emergence of multiple antibiotic resistant bacteria has pushed the available pool of antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource in the development of antibiotics, and the genus Burkholderia has recently emerged as a source of novel compounds with antibacterial, antifungal, and anti-cancer activities. Genome mining has contributed to the identification of biosynthetic gene clusters, which encode enzymes that are responsible for synthesis of such secondary metabolites. Unfortunately, these large gene clusters generally remain silent or cryptic under normal laboratory settings, which creates a hurdle in identification and isolation of these compounds. Various strategies, such as changes in growth conditions and antibiotic stress, have been

SUBMITTER: Thapa SS 

PROVIDER: S-EPMC6963729 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature