A vaccinology Approach to the Identification and Characterization of <i>Dermanyssus Gallinae</i> Candidate Protective Antigens for the Control of Poultry Red Mite Infestations.

ABSTRACT: The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens

SUBMITTER: Lima-Barbero JF 

PROVIDER: S-EPMC6963798 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature