Regorafenib in Combination with First-Line Chemotherapy for Metastatic Esophagogastric Cancer.

ABSTRACT:

Background

Angiogenesis is critical to gastroesophageal adenocarcinoma growth and metastasis. Regorafenib is a multikinase inhibitor targeting angiogenic and stromal receptor tyrosine kinases. We evaluated whether regorafenib augments the antitumor effect of first-line chemotherapy in metastatic esophagogastric cancer.

Materials and methods

Patients with previously untreated metastatic gastroesophageal adenocarcinoma received 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) every 14 days and regorafenib 160 mg daily on days 4 to 10 of each 14-day cycle. The primary endpoint was 6-month progression-free survival (PFS). To identify predictive biomarkers of outcome, we examined correlations between genomic characteristics of sequenced pretreatment tumors and PFS.

Resul

SUBMITTER: Moy RH 

PROVIDER: S-EPMC6964136 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature