Predicting Chemotherapy Toxicity and Death in Older Adults with Colon Cancer: Results of MOST Study.

ABSTRACT:

Purpose

Older patients with colon cancer (CC) are vulnerable to chemotherapy toxicity and death. Establishing simple scores specific for patients with CC to predict severe chemotoxicity or early death is needed to select the best treatment strategy.

Subjects, materials, and methods

This prospective multicenter study included patients aged ≥70 years with CC receiving adjuvant or first-line metastatic chemotherapy. Frailty markers (nutrition, physical activity, energy, mobility, strength), comprehensive geriatric assessment (functional status, comorbidities, falls, nutrition, cognition, and depression), and usual laboratory parameters were collected. Logistic or Cox regression was used to examine at 500 days the association between frailty markers, comprehensive geriatric asse

SUBMITTER: Retornaz F 

PROVIDER: S-EPMC6964155 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature