Patient preferences for maintenance therapy in Crohn's disease: A discrete-choice experiment.

ABSTRACT: OBJECTIVE:To quantify patient preferences for maintenance therapy of Crohn's disease and understand the impact on treatment selection. METHODS:We conducted a discrete-choice experiment in patients with Crohn's disease (n = 155) to measure the importance of attributes relevant to choosing between different medical therapies for maintenance of Crohn's disease. The attributes included efficacy and withdrawals due to adverse events, as well as dosing and other rare risks of treatment. From the discrete-choice experiment we estimated the part-worth (importance) of each attribute level, and explored preference heterogeneity through latent class analysis. We then used the part-worths to apply weights across each outcome from a prior network meta-analysis to estimate patients' preferred treatment

SUBMITTER: Hazlewood GS 

PROVIDER: S-EPMC6964885 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature