New therapeutic approaches for endometriosis besides hormonal therapy.

ABSTRACT:

Objective

Endometriosis is a common gynecologic disease that frequently leading to chronic pelvic pain, severe dysmenorrhea, and subfertility. As first-line hormonal treatment can interfere with ovulation and may cause recurrent pelvic pain, exploration of new non-hormonal therapeutic approaches becomes increasingly necessary. This review aimed to evaluate the pre-clinical and clinical efficacy and safety of non-hormonal treatment for endometriosis DATA SOURCES:: Databases including PubMed, Embase, Cochrane Library, SINOMED, ClinicalTrials.gov, and Google Scholar were searched up to October 2019, using search terms "endometriosis" and "non-hormonal therapy."

Study selection

Twenty-four articles were reviewed for analysis, including nine animal studies and 15 human trials; al

SUBMITTER: Chen FY 

PROVIDER: S-EPMC6964939 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature