Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies.

ABSTRACT: Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeut

SUBMITTER: Melamed E 

PROVIDER: S-EPMC6965059 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature