HDAC10 deletion promotes Foxp3⁺ T-regulatory cell function.

ABSTRACT: Foxp3⁺ T-regulatory (Treg) cells are capable of suppressing immune responses. Lysine acetylation is a key mechanism of post-translational control of various transcription factors, and when acetylated, Foxp3 is stabilized and transcriptionally active. Therefore, understanding the roles of various histone/protein deacetylases (HDAC) are key to promoting Treg-based immunotherapy. Several of the 11 classical HDAC enzymes are necessary for optimal Treg function while others are dispensable. We investigated the effect of HDAC10 in murine Tregs. HDAC10 deletion had no adverse effect on the health of mice, which retained normal CD4⁺ and CD8⁺ T cell function. However, HDAC10^-/- Treg exhibited increased suppressive function in vitro and in vivo. C57BL/6 Ra

SUBMITTER: Dahiya S 

PROVIDER: S-EPMC6965082 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature