Association between lifetime coffee consumption and late life cerebral white matter hyperintensities in cognitively normal elderly individuals.

ABSTRACT: Coffee consumption is associated with cerebral hypoperfusion that may contribute to the development of cerebral white matter hyperintensities (WMH). We investigated the effect of lifetime coffee consumption on the volume of WMH (V_WMH) in late life, and compared the effect between men and women since caffeine clearance may be different between sexes. We enrolled 492 community-dwelling cognitively normal elderly individuals (73.4 ± 6.7 years old on average) from the Korean Longitudinal Study on Cognitive Aging and Dementia. We evaluated their patterns and amounts of coffee consumption using a study-specific standardized interview and estimated cerebral V_WMH by automatic segmentation of brain fluid-attenuated inversion recovery sequence magnetic resonance images. Higher

SUBMITTER: Park J 

PROVIDER: S-EPMC6965088 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature